bählerlab
Genome Regulation
UCL Logo

UCL Home ›› Research Department of Genetics, Evolution and Environment ›› BahlerLab Genome Regulation ›› Home

Home
People
Research
Publications
Resources
Contact

The Bähler laboratory studies cellular quiescence, ageing and long non-coding RNA function using fission yeast and Turquoise Killifish as model systems. We apply diverse genetic, cellular, and systems-level approaches to analyse the regulation and evolution of genomes, complex ageing-associated processes, and relationships between genotype, phenotype and environment.

We are at University College London in the Institute of Healthy Ageing of the Research Department of Genetics, Evolution & Environment. We are also associated with the UCL Cancer Institute, the UCL Genetics Institute, and the Institute of Structural and Molecular Biology. Our research is mainly funded by a Wellcome Trust Senior Investigator Award, BBSRC Project Grants, and a Cancer Research UK Pioneer Award.

 

Selected Publications:

Kamrad S, Grossbach J, Rodríguez-López M, Townsend StJ, Mülleder M, Cappelletti V, Stojanovski G, Picotti P, Beyer A, Ralser M, Bähler J (2020). Pyruvate kinase variant of fission yeast reprograms energy metabolism triggering systemic changes in cell regulation, growth and stress resistance. Molecular Systems Biology 16, e9270

Rodríguez-López M*, Gonzalez S*, Hillson O, Tunnacliffe E, Codlin S, Tallada VA, Bähler J*, Rallis C* (2020). The GATA transcription factor Gaf1 represses tRNAs, inhibits growth, and extends chronological lifespan downstream of fission yeast TORC1. Cell Reports 210, 733

Atkinson SR*, Marguerat S*, Bitton DA*, Rodríguez-López M, Rallis C, Lemay J-F, Cotobal C, Malecki M, Mata J, Bachand F, Bähler J (2018). Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast. RNA 24, 1195

Malecki M, Bitton DA, Rodriguez-Lopez M, Rallis C, Garcia Calavia N, Smith GC, Bähler J (2016). Functional and regulatory profiling of energy metabolism in fission yeast. Genome Biology 17, 240 

Jeffares DC, Rallis C et al. (2015). The genomic and phenotypic diversity of Schizosaccharomyces pombe. Nature Genetics 47, 235–241 

Marguerat S, Schmidt A, Codlin S, Chen W, Aebersold R, Bähler J (2012). Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells. Cell 151, 671-683

Wilhelm BT, Marguerat S, Watt S, Schubert F, Wood V, Goodhead I, Penkett CJ, Rogers J, Bähler J (2008). Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution. Nature 453, 1239-1243