The Bähler laboratory studies cellular quiescence, ageing and gene function using fission yeast and turquoise killifish as model systems. We apply diverse genetic, cellular, and systems-level approaches to analyse the regulation and evolution of genomes, complex ageing-associated processes, and relationships between genotype, phenotype and environment.
We are at University College London in the Institute of Healthy Ageing of the Research Department of Genetics, Evolution & Environment.
Selected Publications:
Rodríguez-López M, Anver S, Cotobal C, Kamrad S, Malecki M, Correia-Melo C, Hoti M, Townsend StJ, Marguerat S, Pong S-K, Wu MY, Montemayor LF, Howell M, Ralser M, Bähler J (2022). Functional profiling of long intergenic non-coding RNAs in fission yeast. eLife 11, e76000
Ellis DA, Reyes-Martín F, Rodríguez-López M, Cotobal C, Sun X-M, Saintain Q, Jeffares DC, Marguerat S, Tallada VA, Bähler J (2021). R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements. . PLoS Genetics 17, e1009784
Kamrad S, Grossbach J, Rodríguez-López M, Townsend StJ, Mülleder M, Cappelletti V, Stojanovski G, Picotti P, Beyer A, Ralser M, Bähler J (2020). Pyruvate kinase variant of fission yeast reprograms energy metabolism triggering systemic changes in cell regulation, growth and stress resistance. Molecular Systems Biology 16, e9270
Malecki M, Kamrad S, Ralser M, Bähler J (2020). Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast. EMBO Reports 21, e50845
Jeffares DC, Rallis C et al. (2015). The genomic and phenotypic diversity of Schizosaccharomyces pombe. Nature Genetics 47, 235–241
Marguerat S, Schmidt A, Codlin S, Chen W, Aebersold R, Bähler J (2012). Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells. Cell 151, 671-683
Wilhelm BT, Marguerat S, Watt S, Schubert F, Wood V, Goodhead I, Penkett CJ, Rogers J, Bähler J (2008). Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution. Nature 453, 1239-1243
