The Bähler laboratory studies cellular quiescence, ageing and long non-coding RNA function using fission yeast and Turquoise Killifish as model systems. We apply diverse genetic, cellular, and systems-level approaches to analyse the regulation and evolution of genomes, complex ageing-associated processes, and relationships between genotype, phenotype and environment.
We are at University College London in the Institute of Healthy Ageing of the Research Department of Genetics, Evolution & Environment, and associated with the UCL Cancer Institute, the UCL Genetics Institute, and the Institute of Structural and Molecular Biology. Our research is mainly funded by a Wellcome Trust Senior Investigator Award, BBSRC Project Grants, and a Cancer Research UK Pioneer Award.
Kamrad S, Grossbach J, Rodríguez-López M, Townsend StJ, Mülleder M, Cappelletti V, Stojanovski G, Picotti P, Beyer A, Ralser M, Bähler J (2020). Pyruvate kinase variant of fission yeast reprograms energy metabolism triggering systemic changes in cell regulation, growth and stress resistance. Molecular Systems Biology 16, e9270
Ellis DA, Mustonen V, Rodríguez-López M, Rallis C, Malecki M, Jeffares DC, Bähler J (2018). Uncovering natural longevity alleles from intercrossed pools of aging fission yeast cells. Genetics 210, 733
Atkinson SR*, Marguerat S*, Bitton DA*, Rodríguez-López M, Rallis C, Lemay J-F, Cotobal C, Malecki M, Mata J, Bachand F, Bähler J (2018). Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast. RNA 24, 1195
Malecki M, Bitton DA, Rodriguez-Lopez M, Rallis C, Garcia Calavia N, Smith GC, Bähler J (2016). Functional and regulatory profiling of energy metabolism in fission yeast. Genome Biology 17, 240
Jeffares DC, Rallis C et al. (2015). The genomic and phenotypic diversity of Schizosaccharomyces pombe. Nature Genetics 47, 235–241
Marguerat S, Schmidt A, Codlin S, Chen W, Aebersold R, Bähler J (2012). Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells. Cell 151, 671-683
Wilhelm BT, Marguerat S, Watt S, Schubert F, Wood V, Goodhead I, Penkett CJ, Rogers J, Bähler J (2008). Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution. Nature 453, 1239-1243
