The Bähler laboratory studies genome regulation during cellular quiescence, ageing and stress response using fission yeast as a model system. We apply multiple genetic, computational and genome-wide approaches for systems-level understanding of regulatory processes and complex relationships between genotype, phenotype, and environment, including roles of genome variation and evolution, transcriptome regulation, and non-coding RNAs.
We are at University College London in the Research Department of Genetics, Evolution & Environment and associated with the UCL Cancer Institute, the Institute of Structural and Molecular Biology, the UCL Genetics Institute, and the Institute of Healthy Ageing. Our research is mainly funded by a Senior Investigator Award from the Wellcome Trust, the BBSRC, a Royal Society Wolfson Research Merit Award, and the EC FP7 PhenOxiGEn project.
Selected Publications:
Jeffares DC, Rallis C et al. (2015). The genomic and phenotypic diversity of Schizosaccharomyces pombe. Nature Genetics 47,235–241
Marguerat S, Schmidt A, Codlin S, Chen W, Aebersold R, Bähler J (2012). Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells. Cell 151, 671-683
Wilhelm BT, Marguerat S, Watt S, Schubert F, Wood V, Goodhead I, Penkett CJ, Rogers J, Bähler J (2008). Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution. Nature 453, 1239-1243
López-Maury L, Marguerat S, Bähler J (2008). Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation. Nature Reviews Genetics 9, 583-593
