The Bähler laboratory studies cellular quiescence, ageing and long non-coding RNA function using fission yeast and, recently, African turquoise killifish as model systems. We apply diverse genetic, cellular, and systems-level approaches to analyse the regulation and evolution of genomes, complex ageing-associated processes, and relationships between genotype, phenotype and environment.
We are at University College London in the Research Department of Genetics, Evolution & Environment and associated with the Institute of Healthy Ageing, the UCL Cancer Institute, the UCL Genetics Institute, and the Institute of Structural and Molecular Biology. Our research is mainly funded by a Wellcome Trust Senior Investigator Award, BBSRC Project Grants, and a Cancer Research UK Pioneer Award.
Ellis DA, Mustonen V, Rodríguez-López M, Rallis C, Malecki M, Jeffares DC, Bähler J (2018). Uncovering natural longevity alleles from intercrossed pools of aging fission yeast cells. Genetics 210, 733
Atkinson SR*, Marguerat S*, Bitton DA*, Rodríguez-López M, Rallis C, Lemay J-F, Cotobal C, Malecki M, Mata J, Bachand F, Bähler J (2018). Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast. RNA 24, 1195
Malecki M, Bitton DA, Rodriguez-Lopez M, Rallis C, Garcia Calavia N, Smith GC, Bähler J (2016). Functional and regulatory profiling of energy metabolism in fission yeast. Genome Biology 17, 240
Jeffares DC, Rallis C et al. (2015). The genomic and phenotypic diversity of Schizosaccharomyces pombe. Nature Genetics 47, 235–241
Marguerat S, Schmidt A, Codlin S, Chen W, Aebersold R, Bähler J (2012). Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells. Cell 151, 671-683
Wilhelm BT, Marguerat S, Watt S, Schubert F, Wood V, Goodhead I, Penkett CJ, Rogers J, Bähler J (2008). Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution. Nature 453, 1239-1243
López-Maury L, Marguerat S, Bähler J (2008). Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation. Nature Reviews Genetics 9, 583-593
